Project track record

Bridging the gap between Basic research and Industrial development

By applying internal capabilities and exploiting funds from national and European Grants, C4T has driven proprietary early discovery projects and gained expertise in specific research areas. Hit identification and Hit to Lead programs are performed in tight collaboration with Academia partners in charge of projects molecular biology.

CB2 Receptor

PIM-1 kinase

Gelatinases (mmp-2/9)

Tγδ

# Molecular Target
1 CB2 Receptor
C4T - Endocannabinoid system - CB2 Receptor
CBR Drug Discovery Platform
  • 3D receptor models validated by in vitro screening
  • Original Focused library of CB2R modulators (WO 2014097188 A1)
    • In vitro potency (EC50 nM)
    • In vitro specificity & selectivity (CB1, FAAH, MAGL)
    • Good in silico ADME-T Profile
2 PIM-1 Kinase
C4T - PIM-1 Inhibitors
Original Focused library of PIM-1 Inhibitors (Unpublished data)
    • In vitro potency (EC50 nM)
    • In vitro specificity & selectivity (wide Kinases panel)
3 Gelatinases
(MMP-2 and MMP-9)

C4T - Gelatinases (MMP-2 and MMP-9)
Original Focused libraries of MMPs inhibitors
    • C4T 1374 Series :
      IC50 pico-molar range ( WO 2008148617 A1)
    • C4T 1360 series - Selective MMP2 inhibitor
      IC50 low nanomolar range ( Bioorg.Med.Chem. 2012)
    • C4T 1466 Series - Non hydroxamate Zinc Binding Group
      IC50 low nanomolar range (Unpublished data)
4 Tγδ linfocytes
C4T - Tγδ linfocytes
New class of Tγδ linfocytes activators ( J.Med.Chem. 2009)

Main Grants

MIUR Cluster Alisei - IVASCOMAR - 2013-2017
Filas II° DTB - INTERACTOMA - 2012-2015
Topic :
Development of new inhibitors of the bacterial cell cycle with low risk of resistance”

Partnerships:
  • ACRAF
  • University of Rome - Tor Vergata
  • Università Cattolica del Sacro Cuore
Funding Schemes:
Regione Lazio - Lazio Innova
VII FP (HEALTH) - FLORINASH - 2010
Topic :
The role of intestinal microflora in NAFLD

Partnerships :
  • INSERM
  • Hospital de Girona
  • University of Rome - Tor Vergata
  • Imperial College
Funding Schemes:
European Union's Research and Innovation
FILAS I° DTB - NUMORECA - 2009
Topic:
New Modulator of Cannabinoid Receptor

Partnerships :
  • University of Rome - Tor Vergata
Funding Schemes:
Regione Lazio - Lazio Innova (ex Filas)
UNESCO - "Families First Africa" - 2007-2009
Topic:
Design, synthesis and experimental check in vitro of immunogenic peptides to be used as HIV-peptides based vaccines

Partnerships :
  • University of Rome "Tor Vergata" (IT) - Prof. V.Colizzi
  • REDD (IT)
  • SARM (IT)
  • University of Rome - Tor Vergata
  • REDD
  • SARM
Funding Schemes:
UNESCO
MIUR FIRB - 2005
Topic:
Design and synthesis of a new Kinase inhibitors

Partnerships : Funding Schemes:
  • Nerviano Medical Science
  • University of Milan
Funding Schemes:
Ministero dell'Istruzione, dell'Universita e della Ricerca
MIUR (n° 2743/99) - 2002
Topic A:
Design and synthesis of a new type of non-proteic antigen like activators of Tγδ lynphocytes

Topic B:
Design and synthesis of new gelatinases (MMP-2 MMP-9) inhibitors

Partnerships :
  • INMI - L.Spallanzani
  • University of Rome - Tor Vergata
Funding Schemes:
Ministero dell'Istruzione, dell'Universita e della Ricerca

Funding Schemes

Research Projects developed thanks to financial support of the following funding schemes:

  • POR FESR Lazio 2007/2013
  • Research & Innovation - FP7
  • LazioInnova
  • MIUR
  • Unesco